Facile synthesis and anticancer activity of novel dihydropyrimidinone derivatives

Abstract The enaminone, (2 E )-3-(dimethylamino)-1-(3,4,5-trimethoxyphenyl) prop-2-en-1-one was prepared by refluxing 3,4,5-trimethoxy acetophenone with dimethylformamide dimethylacetal (DMF–DMA) without solvent for 12 h. dihydropyrimidinone derivatives (1–9) were reacting substituted benzaldehydes and urea in glacial acetic acid. compounds synthesized significant yield using one step multicomponent reaction. Structures of all the novel characterized confirmed various spectroscopic methods. evaluated their anti-cancer activity against HepG2 cancer cell line. Compound 9 displayed activity. During apoptotic assay, it showed a increase necrosis from 1.97% to 12.18% as compared control. Mechanism anti-proliferation performed cycle distribution which decrease G2+M 12.90 8.13